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Synfacts 2010(12): 1338-1338  
DOI: 10.1055/s-0030-1258879
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Trilobacin

Contributor(s): Steven V. Ley, Philippa B. Cranwell
T.-i. Sohn, M. J. Kim, D. Kim*
Seoul National University, Korea
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Publikationsdatum:
22. November 2010 (online)

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Significance

Trilobacin was discovered by McLaughin and co-workers in 1992 from Asimina triloba and is a member of the annonaceous acetogenin family of natural products. It has potent activity against numerous cancer cell lines.