Download PDF
Synfacts 2010(12): 1339-1339  
DOI: 10.1055/s-0030-1258877
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of (±)-Cortistatin A

Contributor(s): Steven V. Ley, Kimberley A. Roper
E. M. Simmons, A. R. Hardin-Narayan, X. Guo, R. Sarpong*
University of California, Berkeley, USA
Further Information

Publication History

Publication Date:
22 November 2010 (online)

    Permissions and Reprints

Significance

The cortistatins are a family of rearranged steroidal alkaloids with an interesting pentacyclic skeleton. These compounds show potent antiproliferative activity against a standard model for anti-angiogenic activity with cortistatin A being the most potent. The cortistatins have become popular targets and three total syntheses, multiple formal syntheses, and numerous synthetic studies have been reported.