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Synfacts 2010(12): 1331-1331  
DOI: 10.1055/s-0030-1258876
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Peloruside A

Contributor(s): Steven V. Ley, Sean Newton
T. R. Hoye*, J. Jeon, L. C. Kopel, T. D. Ryba, M. A. Tennakoon, Y. Wang
University of Minnesota, Minneapolis, USA
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

(+)-Peloruside was isolated from a marine sponge and was found to act as a microtubule stabilizer. This synthesis was published back-to-back with a paper from Jacobsen and co-workers (see Synfacts 2010, 1330). The above ­synthesis of (+)-peloruside A utilizes substrate-controlled diastereoselective transformations and a relay ring-closing metathesis.