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Synfacts 2010(12): 1335-1335  
DOI: 10.1055/s-0030-1258873
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Barekoxide and (-)-Barekol

Contributor(s): Steven V. Ley, James R. Frost
Y. Lian, L. C. Miller, S. Born, R. Sarpong*, H. M. L. Davies*
Emory University, Atlanta and University of California, Berkeley, USA
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Publikationsdatum:
22. November 2010 (online)

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Significance

(+)-Barekoxide and (-)-barekol both contain seven-membered rings, which can be ­stereoselectively produced via a formal [4+3] ­cycloaddition involving a tandem cyclopropanation-Cope rearrangement sequence.