Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2010(12): 1340-1340
DOI: 10.1055/s-0030-1258870
DOI: 10.1055/s-0030-1258870
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Tenofovir Disoproxil Fumarate
D. H. Brown Ripin*, D. S. Teager et al.*
Clinton Health Access Initiative, Boston, Howard University, Washington, Purdue University, West Lafayette and ProcesScience, Fayetteville, USA; University of Ottawa, Canada; Inogent Laboratories, Hyderabad and Aptuit Laurus Pvt., Hyderabad, India
Further Information
Publication History
Publication Date:
22 November 2010 (online)
Significance
Tenofovir is a reverse transcriptase inhibitor used in combination with other antiretroviral agents for the treatment of HIV and chronic hepatitis B. It is administered once daily as the hydrolytically labile prodrug tenofovir disoproxil fumarate. The route depicted is a substantially optimized version of the manufacturing route that increased the overall yield from 13% to 24%.