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Synfacts 2010(12): 1336-1336  
DOI: 10.1055/s-0030-1258868
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of an LFA-1 Inhibitor

Contributor(s): Philip Kocienski
X.-j. Wang*, Y. Xu, L. Zhang, D. Krishnamurthy, T. Wirth*, T. Nicola, C. H. Senanayake
Boehringer Ingelheim Pharmaceuticals, Ridgefield, USA; Boehringer Ingelheim, Ingelheim am Rhein, Germany
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Publikationsdatum:
22. November 2010 (online)

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Significance

Inhibitors of lymphocyte function-associated antigen 1 (LFA-1) are potential drugs for the treatment of inflammatory and immune disorders. The concise and robust five-stage process depicted delivered the target LFA-1 inhibitor on a one metric ton scale in 53% overall yield.