Synfacts 2010(12): 1383-1383  
DOI: 10.1055/s-0030-1258865
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Gold(I)-Catalyzed Diastereoselective Pyrrolidine Synthesis

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
M.-C. P. Yeh*, M.-N. Lin, W.-J. Chang, J.-L. Liou, Y.-F. Shih
National Taiwan Normal University, Taipei, Taiwan
Further Information

Publication History

Publication Date:
22 November 2010 (online)

Significance

The authors report a completely ­diastereoselective gold(I)-catalyzed cyclization to form cis-3-acyl-4-alkyenylpyrrolidines. Pyrrolidine products were formed in very nice yields, and this methodology can be extended to cyclopentane derivatives as well.