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Synfacts 2010(12): 1405-1405
DOI: 10.1055/s-0030-1258863
DOI: 10.1055/s-0030-1258863
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Nickel-Catalyzed C-O Activation of Phenol Derivatives
G. A. Molander*, F. Beaumard
University of Pennsylvania, Philadelphia, USA
Further Information
Publication History
Publication Date:
22 November 2010 (online)
Significance
The first general nickel-catalyzed method for C-O activation with aryl- and hetero-aryltrifluoroborates is reported. Various mesylated phenol- and heteroaryl derivatives are used as coupling partners. Ni(cod)2 is the catalyst of choice, other nickel species did not prove to be active in this reaction.