Zinc Alkoxide Catalyzed Allylations of Ketones with Allyl
Pinacol Boronates

K. R. Fandrick; D. R. Fandrick; J. J. Gao; J. T. Reeves; Z. Tan; W. Li; J. J. Song; B. Lu; N. K. Yee; C. H. Senanayake

doi:10.1055/s-0030-1258860

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Synfacts 2010(12): 1408-1408
DOI: 10.1055/s-0030-1258860

Metal-Mediated Synthesis

Zinc Alkoxide Catalyzed Allylations of Ketones with Allyl Pinacol Boronates

Contributor(s): Paul Knochel, Andreas J. Wagner
K. R. Fandrick*, D. R. Fandrick, J. J. Gao, J. T. Reeves, Z. Tan, W. Li, J. J. Song, B. Lu, N. K. Yee, C. H. Senanayake
Boehringer Ingelheim Pharmaceuticals, Ridgefield, USA

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Publication History

Publication Date:
22 November 2010 (online)

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Significance

An efficient, general allylation of a wide range of ketones with allyl boronates is disclosed. A zinc alkoxide (2 mol%) serves as catalyst, enabling relatively short reaction times.