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Synfacts 2010(12): 1414-1414  
DOI: 10.1055/s-0030-1258855
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Magnesium in Direct Coupling of Benzylic Halides with Pinacolborane

Contributor(s): Paul Knochel, Thomas Kunz
C. Pintaric, S. Olivero, Y. Gimbert, P. Y. Chavant, E. Duñach*
Université de Nice-Sophia Antipolis and Université Joseph Fourier, Grenoble, France
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

A protocol for the synthesis of ­benzylboronic pinacol esters from benzylic halides is disclosed. This one-pot procedure is simple, clean and efficient, whereby the coupling step does not require any transition-metal catalyst. Magnesium, as the only metal involved, is only used in catalytic amounts (10 mol%).