Cross-Coupling of Aryltrimethylammonium Triflates with Aryl Grignard Reagents

Significance

A mild and general method for the cross-coupling of aryltrimethylammonium triflates with aryl organomagnesium reagents was developed. The reaction proceeds best under palladium catalysis at ambient temperature. Functional groups, such as ester functionalities, are well tolerated due to the fact that only a slight excess of Grignard reagent is used. Methylation of N,N-di­methylanilines and subsequent cross-coupling of the resulting aryltrimethylammonium triflate could be combined in a one-pot procedure leading to an increase in reaction times.