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Synfacts 2010(12): 1404-1404  
DOI: 10.1055/s-0030-1258849
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Csp³-Csp³ Suzuki Cross-Coupling Using Unactivated Secondary Alkyl Chlorides

Contributor(s): Paul Knochel, Tobias Thaler
Z. Lu, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

This article reports an efficient method for the nickel-catalyzed Suzuki cross-coupling of unactivated secondary alkyl chlorides. The reaction proceeds under mild conditions at ambient temperature. The catalyst components are commercially available and inexpensive. The coupling proved to be general, and could thus be applied to a broad range of unactivated secondary alkyl chlorides.