Pd-Catalyzed γ-Arylation of α,β-Unsaturated Esters from Silyl Ketene Acetals

Significance

Herein, a new γ-selective arylation of α,β-unsaturated esters is reported by coupling aryl, heteroaryl or vinyl halides with the corrsponding silicon dienolates. The procedure tolerates ­reactive functional groups and proceeds in high yields even for sterically challenging substrates. The products are valuable compounds only available in multi-step sequences by conventional methods.