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Synfacts 2010(11): 1213-1213  
DOI: 10.1055/s-0030-1258715
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of the Ecklonialactones

Contributor(s): Steven V. Ley, Kimberley A. Roper
V. Hickmann, M. Alcarazo, A. Fürstner*
Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

The ecklonialactones are a family of C18 oxylipins isolated from various brown algae. This first synthesis is protecting-group-free and features two ring-closing metathesis steps. This route was also used to access ecklonialactone A (which is saturated between C6 and C7) from common intermediate I.