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Synfacts 2010(11): 1219-1219  
DOI: 10.1055/s-0030-1258711
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Virginiamycin M2

Contributor(s): Steven V. Ley, Philippa B. Cranwell
J. Wu, J. S. Panek*
Boston University, USA
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

Virginiamycin M2 is a naturally ­occurring antibiotic produced by Streptomyces. Derivatives of the virginiamycins display potent antibiotic activity against methicillin-, erythro­mycin-, and vancomycin-resistant S. aureus and have led to drugs which have been used to treat severe Gram-positive bacterial infections.