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Synlett 2010(17): 2589-2592  
DOI: 10.1055/s-0030-1258574
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Concise Total Synthesis of Vicenistatin

Hayato Fukudaa, Shiina Nakamuraa, Tadashi Eguchib, Yoshiharu Iwabuchia, Naoki Kanoh*a
a Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
Fax: +81(22)7956847; e-Mail: kanoh@mail.pharm.tohoku.ac.jp;
b Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan
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Publication History

Received 21 July 2010
Publication Date:
23 September 2010 (online)

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Abstract

A highly convergent total synthesis of macrocyclic lactam glycoside vicenistatin is described. Key features of the synthesis include rapid assembly of the macrolactam part and macrocyclic ring closure via intramolecular Stille coupling.

Key words

vicenistatin - macrolactam - vicenisamine - total synthesis

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