Copper(II) Oxide Catalyzed Ligand-Free Coupling Reaction of Heteroarenes with Bromoalkynes [¹]

Abstract

The coupling reaction of imidazoles and pyrazoles with bromoacetylenes has efficiently been carried out under ligand-free conditions in the presence of copper(II) oxide as the catalyst using potassium hydroxide in 1,4-dioxane at 80 ˚C. The method is a simpler access to N-alk-1-ynyl- and/or N-(2-bromovinyl)-substituted heteroarenes.

coupling reaction - ligand-free conditions - copper(II) oxide - N-alkynylheteroarene - N-(2-bromovinyl)heteroarene

References

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Part 217 in the series ‘Studies on novel synthetic methodologies’.

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