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Synthesis 2011(2): 223-228
DOI: 10.1055/s-0030-1258357
DOI: 10.1055/s-0030-1258357
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkA Novel Approach to 1-Monosubstituted 1,2,3-Triazoles by a Click Cycloaddition/Decarboxylation Process
Further Information
Received
12 October 2010
Publication Date:
07 December 2010 (online)
Publication History
Publication Date:
07 December 2010 (online)
Abstract
The synthesis of 1-monosubstituted 1,2,3-triazoles was achieved using azides and propiolic acid by copper-catalyzed click cycloaddition/decarboxylation, which was easily carried out in N,N-dimethylformamide at room temperature or 60 ˚C with yields ranging from moderate to excellent. The reaction conditions were found to be successful for aryl and vinyl azide reactants, including analogues with various functionalities.
Key words
click chemistry - copper catalysis - decarboxylation - heterocycle - 1-monosubstituted 1,2,3-triazole
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- Supporting Information
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