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Synthesis 2010(23): 4087-4095  
DOI: 10.1055/s-0030-1258277
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Synthesis of Naturally Occurring Skeleton 5-7-6 Tricyclic Pyrrolo[2,1-c][1,4]benzodiazepin-5-one and Its Derivatives via Cationic π-Cyclization [¹]

Sudhir K. Sharmaa, Anil K. Mandadapua, K. Kumaresana, Ashish Arorab, Harsh M. Gauniyalc, Bijoy Kundu*a
a Division of Medicinal and Process Chemistry, Central Drug Research Institute, CSIR, Lucknow, 226001, India
Fax: +91(522)2623405; e-Mail: bijoy_kundu@yahoo.com; e-Mail: b_kundu@cdri.res.in;
b Division of Molecular & Structural Biology, Central Drug Research Institute, CSIR, Lucknow, 226001, India
c Sophisticated Analytical Instrument Facility, Central Drug Research Institute, CSIR, Lucknow, 226001, India
Further Information

Publication History

Received 3 June 2010
Publication Date:
28 September 2010 (online)

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Abstract

An efficient method for the synthesis of a library based on the naturally occurring 5-7-6 tricyclic 5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one skeleton and its derivatives via cationic π-(7-endo) cyclization is described.

Key words

pyrrole - antibiotics - π-cyclization - oxidation - reduction

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CDRI communication no. 7931.

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CDRI communication no. 7931.