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Synthesis 2010(22): 3891-3898
DOI: 10.1055/s-0030-1258253
DOI: 10.1055/s-0030-1258253
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkConvergent Synthesis of Passifloricin A via a Prins Cyclisation and Olefin Cross-Metathesis Approach
Further Information
Received
2 August 2010
Publication Date:
17 September 2010 (online)
Publication History
Publication Date:
17 September 2010 (online)
Abstract
A stereoselective and convergent approach to the total synthesis of the natural product passifloricin A is illustrated using Prins cyclisation and metathesis reactions as key steps.
Key words
passifloricin A - Prins cyclisation - cross-metathesis - ring-closing metathesis - lithium aluminum hydride-lithium iodide
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References
Passifloricin A has been found to be active against some Plasmodium and Leishmania spp. (Echeverri, F. personal communication).