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Synthesis 2010(21): 3637-3644  
DOI: 10.1055/s-0030-1258237
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Suzuki-Miyaura Cross-Coupling of 3-Pyridyl Triflates with Alk-1-enyl-2-pinacol Boronates

James R. Vyvyan*, Jennifer A. Dell, Toby J. Ligon, Kelsey K. Motanic, Hayley S. Wall
Department of Chemistry, Western Washington University, 516 High Street, Bellingham, WA 98225-9150, USA
Fax: +1(360)6502826; e-Mail: vyvyan@chem.wwu.edu;
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Publication History

Received 8 July 2010
Publication Date:
30 August 2010 (online)

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Abstract

Palladium-catalyzed Suzuki-type couplings of 3-pyridyl triflates with alkenylpinacol boronates proceed in good to excellent yields. Optimized conditions use Pd(PPh3)4 (10 mol%) as catalyst with K3PO4 (3 equiv) as base in 1,4-dioxane.

Key words

boron - cross-coupling - heterocycles - palladium - pyridines

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