Friedel-Crafts Reactions
of 2-Naphthol with α-Amido Sulfones and Conversion
of the Products with Nucleophiles

Biswanath Das; Cheruku Ravindra Reddy; Chava Sindhu; Chithaluri Sudhakar; Siddavatam Nagendra

doi:10.1055/s-0030-1258218

PAPER

Friedel-Crafts Reactions of 2-Naphthol with α-Amido Sulfones and Conversion of the Products with Nucleophiles [¹]

Biswanath Das*, Cheruku Ravindra Reddy, Chava Sindhu, Chithaluri Sudhakar, Siddavatam Nagendra
Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27193198; e-Mail: biswanathdas@yahoo.com;

Abstract

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Abstract

2-Naphthol underwent Friedel-Crafts reaction with N-benzyloxycarbonylamino sulfones in the presence of InCl₃ at room temperature to form the corresponding sulfonyl derivatives in high yields. The products were subsequently reacted with nucleophiles such as allyltributyltin and anisole to replace the sulfonyl group.

Key words

2-naphthol - α-amido sulfone - InCl₃ - Friedel-Crafts reaction - nucleophile

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References

Part 209 in the series ‘Studies on Novel Synthetic Methodologies’.

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