Aryl ketoximes readily underwent Beckmann rearrangement to give
N-substituted amides in excellent yields on electrophilic activation
by elemental iodine in anhydrous acetonitrile under reflux. The
main advantages of this environmentally friendly protocol include
a high selectivity as a result of the absence of any accompanying
deprotection to form the parent ketones as byproducts, mild neutral
conditions, procedural simplicity, and particularly ease of isolation
of the products.
rearrangements - amides - ketoximes - catalysis - Beckmann rearrangements
