Synthesis 2010(16): 2705-2707  
DOI: 10.1055/s-0030-1258173
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple and Efficient Asymmetric Synthesis of Anxiolytic Drug Enciprazine

A. Venkat Narsaiah*, B. Nagaiah
Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500007, India
Fax: +91(40)27160387; e-Mail: vnakkirala2001@yahoo.com;
Further Information

Publication History

Received 23 March 2010
Publication Date:
12 July 2010 (online)

Abstract

A straightforward and efficient asymmetric synthesis of (S)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphen­oxy)propan-2-ol is described. The key intermediate, (S)-2-[(3,4,5-trimethoxyphenoxy)methyl]oxirane, was obtained by a hydrolytic kinetic resolution method using the catalyst (R,R)-salen-cobalt(III) complex.

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