Download PDF
Synfacts 2010(10): 1108-1108  
DOI: 10.1055/s-0030-1258070
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a c-Met Kinase Inhibitor

Contributor(s): Philip Kocienski
G. W. Stewart et al.*
Merck Sharp & Dohme Research Laboratories, Hoddesdon, UK; Merck & Co., Boston, USA
Further Information

Publication History

Publication Date:
22 September 2010 (online)

    Permissions and Reprints

Significance

Aberrant activation of mesenchymal epithelial transition factor (c-Met) increases the metastatic potential of tumor cells. Inhibitors of c-Met may suppress tumor aggressiveness and prolong the life of cancer patients. The large-scale convergent synthesis of the target c-Met kinase inhibitor was accomplished in 29% overall yield.