Asymmetric Rh(II)- and Cu(I)-Catalyzed Si-H Insertion
Leading to Chiral Crotylsilanes

doi:10.1055/s-0030-1257817

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Synfacts 2010(8): 0914-0914
DOI: 10.1055/s-0030-1257817

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Asymmetric Rh(II)- and Cu(I)-Catalyzed Si-H Insertion Leading to Chiral Crotylsilanes

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
J. Wu, Y. Chen, J. S. Panek*
Boston University, USA

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Publikationsverlauf

Publikationsdatum:
22. Juli 2010 (online)

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Significance

Application of Davies’ Rh₂(DOSP)₄ complex affords carbene insertions to α-diazovinylacetates to give chiral crotylsilanes. These silanes can then be applied under previously reported conditions to yield vinylogous aldol products with high diastereo- and enantioselectivity.