Hypertensiologie 2010

Was ist neu?

• Zielblutdruckwerte: Neubewertung in der ESH-Hypertonieleitlinie.

• Nierenarterienstenose: Konservative Therapie bevorzugen.

• Sartane: Auch gegen Demenz wirksam?

• Resistente Hypertonie: Endothelin-Antagonist von Vorteil?

• Neuer Vasopeptidasehemmer: Kombination von zwei antihypertensiven Wirkprinzipien erfolgversprechend.

• Impfung gegen Angiotensin II: Hoffnungen nicht bestätigt.

Literatur

• 1 Bax L. et al . Stent Replacement in Patients with Atherosclerotic Renal Artery Stenosis and Impaired Renal Function.  Ann Intern Med. 2009;  150 840-848
• 2 Hansson L. et al . Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal treatment (HOT) randomised trial.  Lancet. 1998;  351 1755
• 3 Li N C, Lee A, Whitmer R A. et al . Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis.  BMJ. 2010;  340 b5409
• 4 Mancia G, Laurent S, Agabiti-Rosei E. et al . Reappraisal of the European Hypertension Guidelines.  J Hypertens. 2009;  27 2121-2158
• 5 Middeke M. Hypertensiologie 2008.  Dtsch Med Wochenschr. 2008;  133 1344-1347
• 6 Middeke M. Hypertensiologie 2009.  Dtsch Med Wochenschr. 2009;  134 1312-1315
• 7 Ruilope L M, Dukat A, Böhm M. et al . Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study.  Lancet. 2010;  375 1255-1266
• 8 Sink K M, Leng X, Williamson J. et al . Angiotensin-Converting Enzyme Inhibitors and Cognitive Decline in Older Adults With Hypertension.  Arch Intern Med. 2009;  169 1195-1202
• 9 The ACCORD Study Group . Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus.  N Engl J Med. 2010;  362 1575-1585
• 10 The ASTRAL Investigators . Revascularization versus Medical-Therapy for Renal-Artery Stenosis.  N Engl J Med. 2009;  361 1953-1962
• 11 Weber M A, Black H, Bakris G. et al . A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistent hypertension: a randomised, double-blind, placebo-controlled trial.  Lancet. 2009;  374 1423-1431