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DOI: 10.1055/s-0030-1254107
© Georg Thieme Verlag KG Stuttgart · New York
CD Rats as an Animal Model in the Experimental Study of Laparoscopic Hernia Repair
Publication History
received January 21, 2010
accepted after revision March 01, 2010
Publication Date:
25 May 2010 (online)

Abstract
Purpose: The aim of this study was to evaluate the technical feasibility and efficacy of a sutureless laparoscopic hernia repair in a small animal model. The objective was to occlude the processus vaginalis with biocompatible fleece and/or fibrin glue as an alternative to suturing.
Methods: Sixty-three male CD rats were randomly assigned to one of three groups. In group A (n=21), the internal inguinal ring was filled with 0.5 ml fibrin glue. The second group (B, n=21) also received fibrin glue, and a biocompatible fleece was placed on top. The third group consisted of control animals (C, n=21). Eleven rats in each group underwent laparoscopic surgery. The remaining rats were operated using an open technique, and the paraductal lipomas were resected in addition to inguinal ring closure.
Results: Complete closure of the internal hernia ring was not achieved in any of the rats, neither in the laparoscopic group nor in the open group or the control group. The paraductal lipoma grew back to its normal size, although resection of the lipoma was performed during the first procedure.
Conclusion: The physiology of paraductal lipomas in this animal appears to make it an inadequate model for the study of laparoscopic inguinal hernia repair.
Key words
animal investigation - child - hernia repair - laparoscopy - minimally invasive
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Correspondence
Dr. Salmai Turial
University Medical Center
Department of Pediatric
Surgery
Langenbeckstraße 1
55101 Mainz
Germany
Phone: +49 6131 17 7107
Fax: +49 6131 17 6523
Email: salmai.turial@unimedizin-Mainz.de