Planta Med 2011; 77(7): 736-741
DOI: 10.1055/s-0030-1250534
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Chemical Constituents and Antitubercular Activity of Formosan Pisonia umbellifera

Hsiou-Ting Kuo1 , Chien-Fang Peng2 , Hung-Yi Huang1 , Chu-Hung Lin3 , Ih-Sheng Chen1 , 3 , Ian-Lih Tsai1 , 3
  • 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R. O. C.
  • 2Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, R. O. C.
  • 3School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R. O. C.
Further Information

Publication History

received August 23, 2010 revised Sept. 30, 2010

accepted October 16, 2010

Publication Date:
24 November 2010 (online)

Abstract

Bioassay-guided fractionation of the methanolic extract of the stem of Pisonia umbellifera (Nyctaginaceae) afforded the three new compounds, secopisonic acid (1), 6,8-dimethylisogenistein (2), and (+)-ent-ficusol (3), and four first isolates from nature, pisoninol I (4), pisoninol II (5), pisoquinoline (6), and pisodienone (7), together with fifteen known compounds. Their structures were elucidated by analysis of spectroscopic data. Seven of these isolates, 3, 7, 12, 16, 18, 20, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37RV in vitro, with MIC values ≤ 50 µg/mL.

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Prof. Dr. Ian-Lih Tsai

School of Pharmacy, College of Pharmacy
Kaohsiung Medical University

100, Shi-hChuan 1st Road

Kaohsiung, Taiwan 807

Republic of China

Phone: +88 6 73 12 11 01 ext. 26 64

Fax: +88 6 73 21 06 83

Email: ialits@kmu.edu.tw

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