Phenolic Constituents of Selaginella doederleinii

Rui Chao Lin; Alexios-Léandros Skaltsounis; Elisabeth Seguin; François Tillequin; Michel Koch

doi:10.1055/s-2006-959443

Planta Medica, Inhaltsverzeichnis

Planta Med 1994; 60(2): 168-170
DOI: 10.1055/s-2006-959443

Papers

Phenolic Constituents of Selaginella doederleinii

Rui Chao Lin¹ ^, ² , Alexios-Léandros Skaltsounis¹ , Elisabeth Seguin¹ , François Tillequin¹ , Michel Koch¹

¹Laboratoire de Pharmacognosie, U.R.A. au C.N.R.S. n° 1310, Faculté de Pharmacie, Université Paris V, 4 Avenue de l'Observatoire, F-75006 Paris, France
²Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Dijon, 7 Boulevard Jeanne d'Arc, F-21033 Dijon Cedex, France

Abstract

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Abstract

Eleven phenolic Compounds have been isolated from the ethanolic extract of Selaginella doederleinii by a combination of Chromatographic techniques. These are five lignans: (-)-lirioresinol A, (-)-lirioresinol B, (+)-wikstromol, (-)-nortracheloside, (+)-matairesinol (1), two phenylpropanones: 3-hydroxy-1-(3-methoxy-4-hydroxyphenyl)-propan-1-one (2), 3-hydroxy-1-(3,5 -dimethoxy-4-hydroxyphenyl)-propan-1-one (3), and four biflavonoids: amentoflavone, 7,7″-di-O-methylamentoflavone, 7,4′,7″,4‴-tetra-O-methylamentoflavone, and heveaflavone (4). Compounds 1, 2, and 3 are novel natural secondary metabolites. Their structures were deduced from their spectral data (mainly ¹H-NMR, mass, and CD). Lignans are described here for the first time in the family Selaginellaceae. Their cytotoxic activity against L 929 murine cells accounts for the use of the plant in traditional Chinese medicine as an anticancer agent.

Key words

Selaginella doederleinii - Selaginellaceae - Pteridophyta - phenylpropanones - lignans - biflavonoids - cytotoxic activity - Chinese traditional medicine

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