Daptomycin Use in a Neonate: Serum Level Monitoring and Outcome

ABSTRACT

We present a case of successfully treated persistent bacteremia due to Gram-positive bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses (6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults with no adverse events. Peak and trough serum concentrations of daptomycin were 22.9 and 11.6 μg/mL at day 4 as well as 27.3 and 7.9 μg/mL at day 11 after initiation of treatment, respectively.

KEYWORDS

Daptomycin - neonate - drug monitoring - enterococcal bacteremia

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