DMW - Deutsche Medizinische Wochenschrift, Inhaltsverzeichnis Dtsch Med Wochenschr 2009; 134: S386-S389DOI: 10.1055/s-0029-1243047 Übersicht | Review articlePneumologie© Georg Thieme Verlag KG Stuttgart · New YorkWechselwirkung zwischen inhalativen Kortikosteroiden und langwirksamen Beta-2-SympathomimetikaInteraction between inhaled corticosteroids and long-acting beta-2-agonistsP. Kardos1 1Institut Gemeinschaftspraxis und Zentrum für Pneumologie, Allergologie & Schlafmedizin, Klinik Maingau Artikel empfehlen Abstract Artikel einzeln kaufen Schlüsselwörter Asthma bronchiale - inhalatives Kortikosteroid - langwirksamer Beta-2-Rezeptoragonist - Asthma-Pathogenese Keywords asthma - long-acting beta2-agonist - inhaled corticosteroid - asthma pathogenesis Volltext Referenzen Literatur 1 Baraniuk J N, Ali M, Brody D. et al . Glucocorticoids induce beta2-adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med. 1997; 155 704-710 2 Barnes P J. Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J. 2002; 19 182-191 3 The Global Initiative for Asthma (GINA) 2008. www.ginasthma.com/Guidelineitem.asp??l1 = 2&l2 = 1&intId = 60. (letzter Zugriff am 2.1.2009. 4 Greening A P, Ind P W, Northfield M, Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group. Lancet. 1994; 344 219-224 5 Ichinose M, Takahashi T, Sugiura H. et al . Baseline airway hyperresponsiveness and its reversible component: role of airway inflammation and airway calibre. Eur Respir J. 2000; 15 248-253 6 Ind P W, Dal Negro R, Colman N C, Fletcher C P, Browning D, James M H. Addition of salmeterol to fluticasone propionate treatment in moderate-to-severe asthma. Respir Med. 2003; 97 555-562 7 Lakser O J, Dowell M L, Hoyte F L. et al . Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur Respir J. 2008; 32 1224-1230 8 Maneechotesuwan K, Essilfie-Quaye S, Meah S. et al . Formoterol attenuates neutrophilic airway inflammation in asthma. Chest. 2005; 128 1936-1942 9 Pauwels R A, Löfdahl C G, Postma D S. et al . Effect of inhaled formoterol and budesonide on exacerbations of asthma-- Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med. 1997; 337 1405-1411 , [Erratum appears in N Engl J Med 1998 Jan 8; 338: 139] 10 Roth M, Johnson P R, Rüdiger J J. et al . Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet. 2002; 360 1293-1299 11 Tulic M K, Christodoulopoulos P, Hamid Q. Small airway inflammation in asthma. Respir Res. 2001; 2 333-339 12 Usmani O S, Biddiscombe M F, Barnes P J. Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med. 2005; 172 1497-1504 13 Usmani O S, Ito K, Maneechotesuwan K. et al . Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med. 2005; 172 704-712 14 Woolcock A, Lundback B, Ringdal N, Jacques L A. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med. 1996; 153 1481-1488 Dr. Peter Kardos Gemeinschaftspraxis & Zentrum für Pneumologie, Allergologie & Schlafmedizin Klinik Maingau Scheffelstraße 33 60318 Frankfurt am Main Telefon: 069/553611 eMail: pkardos@aol.com