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DOI: 10.1055/s-0029-1220889
© Georg Thieme Verlag KG Stuttgart · New York
Nasal Bleeding Associated with Fluoxetine and Risperidone Interaction: A Case Report
Publikationsverlauf
received 12.11.2008
revised 23.12.2008
accepted 15.01.2009
Publikationsdatum:
01. September 2009 (online)

Here we report a 22-year-old man with schizophrenia who developed nasal bleeding with the fluoxetine and risperidone combination. Nasal bleeding was not observed with either fluoxetine or risperidone alone. A variety of mechanisms might explain this bleeding side effect of the fluoxetine and risperidone combination. Our experience highlights that more attention needs to be paid to this combination, especially in susceptible patients.
References
- 1 Calhoun JW, Calhoun DD. 1996 Prolonged bleeding time in a patient treated with sertraline. Am J Psychiatry. 1996; 153 443
- 2 Fountoulakis KN, Samolis S, Iacovides A, St Kaprinis G. Ecchymoses as an adverse effect of fluoxetine treatment. Psychiatry Res. 2007; 152 91-92
- 3 Harrison-Woolrych M, Clark DWJ. Nose bleeds associated with use of risperidone. BMJ. 2004; 328 1416
- 4 Hudson RG, Cain MP. Risperidone associated hemorrhagic cystitis. J Urol. 1998; 160 159-160
- 5 Ootsuka Y, Nalivaiko E, Blessing WW. Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine, Ecstasy) and its reversal by clozapine. Brain Res. 2004; 1014 34-44
- 6 Spina E, Avenoso A, Scordo MG. et al . Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction. J Clin Psychopharmacol. 2002; 22 419-423
Correspondence
A. MowlaMD
Department of Psychiatry
Persian Gulf Bioscience Research Center
Bushehr University of Medical Sciences
Bushehr
Iran
Telefon: +98/917/313 20 01
Fax: +98/711/627 93 19
eMail: mowlaar@gmail.com