Synfacts 2010(7): 0829-0829  
DOI: 10.1055/s-0029-1220123
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Bifunctional Chiral Brønsted Acid/Base Organocatalysis

Contributor(s): Benjamin List, Anna Lee
V. N. Wakchaure, B. List*
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
Further Information

Publication History

Publication Date:
22 June 2010 (online)

Significance

A novel bifunctional chiral Brønsted acid/base catalyst is reported. The authors applied the new catalyst 1 to the enantioselective desymmetrization of meso-anhydrides, and the products were obtained in good yields and high enantioselectivities (er up to 99:1). The synthetic utility of this methodology was demonstrated in the symmetric formal synthesis of (+)-grandisol.