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Synfacts 2010(7): 0791-0791  
DOI: 10.1055/s-0029-1220110
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Quaternary Stereocenters Generated by Conjugate Addition of α-Cyano Ketones

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
Y. Kawato, N. Takahashi, N. Kumagai*, M. Shibasaki*
The University of Tokyo, Japan
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Publication History

Publication Date:
22 June 2010 (online)

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Significance

Highly functionalized molecules with an all-carbon quaternary stereocenter can be readily attained with ligand 1 and Y(Oi-Pr)3. This nice catalyst system can be further used to synthesize enantioenriched bicyclic compounds, which can have synthetic value.