Highly Selective Copper-Catalyzed Tandem Michael Addition/Mannich
Reaction

doi:10.1055/s-0029-1220109

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Synfacts 2010(7): 0808-0808
DOI: 10.1055/s-0029-1220109

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Highly Selective Copper-Catalyzed Tandem Michael Addition/Mannich Reaction

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
S. Guo, Y. Xie, X. Hu, C. Xia, H. Huang*
Lanzhou Institute of Chemical Physics, Zhejiang University of Technology, Hangzhou and Graduate School of Chinese Academy of Sciences, Beijing, P. R. of China

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Publication History

Publication Date:
22 June 2010 (online)

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Significance

A copper/zinc catalyst system is used to initiate a tandem Michael addition/Mannich reaction to form highly interesting chiral isoindolinones and azetidines. The process is highly diastereo- and enantioselective in forming these heterocycles.