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Synfacts 2010(7): 0838-0838  
DOI: 10.1055/s-0029-1220090
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Imidazo[1,2-a]pyrimidin-5-ones on a Polymer Support

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Toshihiro Watanabe
C. H. Soh, Y. Lam*
National University of Singapore, Singapore
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Publication History

Publication Date:
22 June 2010 (online)

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Significance

A microwave-assisted solid-phase synthesis of 2-(benzylthio)imidazo[1,2-a]pyrimidin-5(1H)-ones 4 was described. Treatment of polymer-supported mercaptopyrimidin-4-ones 2, prepared from β-keto esters 1 and thiourea, with bromoacetonitrile followed by the sequential ­cyclization and cleavage gave 2-(benzylthio)-imidazo[1,2-a]pyrimidin-5(1H)-ones 4 in 35-46% overall yield.