Download PDF
Synfacts 2010(7): 0779-0779  
DOI: 10.1055/s-0029-1220083
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Cross-Coupling of Activated Secondary Alkyl Electrophiles

Contributor(s): Mark Lautens, David A. Candito
S. Lou, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA
Further Information

Publication History

Publication Date:
22 June 2010 (online)

    Permissions and Reprints

Significance

Building upon previous work (X. Dai, N. A. Strotman, G. C. Fu J. Am. Chem. Soc. 2008, 130, 3302) the authors report on the nickel-catalyzed asymmetric cross-coupling of alkenylzirconium reagents with α-bromo ketones. This work is valuable as there are limited reports on the alkenylation of secondary electrophiles. Furthermore, this report is the first to demonstrate the coupling of activated secondary alkyl electrophiles with organozirconium reagents.