Download PDF
Synfacts 2010(7): 0821-0821  
DOI: 10.1055/s-0029-1220051
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Transition-Metal-Free Amination of Aryl Grignard Reagents

Contributor(s): Paul Knochel, Stefan Wunderlich
T. Hatakeyama, Y. Yoshimoto, S. K. Ghorai, M. Nakamura*
Kyoto University, Uji, Japan
Further Information

Publication History

Publication Date:
22 June 2010 (online)

    Permissions and Reprints

Significance

In the presence of N,N,N′,N′-tetra­methylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines ­react with aryl and heteroaryl Grignard reagents at low temperatures giving a variety of aryl amines in good to excellent yields. Functional groups, such as ester and nitrile, are compatible under these ­reaction conditions.