Transition-Metal-Free Amination of Aryl Grignard Reagents

Significance

In the presence of N,N,N′,N′-tetra­methylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines ­react with aryl and heteroaryl Grignard reagents at low temperatures giving a variety of aryl amines in good to excellent yields. Functional groups, such as ester and nitrile, are compatible under these ­reaction conditions.