Synfacts 2010(7): 0816-0816  
DOI: 10.1055/s-0029-1220038
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Base-Free Aryl Coupling of Diazonium Compounds and Boronic Esters

Contributor(s): Paul Knochel, Andreas J. Wagner
H. Bonin, D. Delbrayelle, P. Demonchaux, E. Gras*
Université Paul Sabatier, Toulouse, Minakem, Beuvry-La-Forêt and Université de Toulouse, France
Further Information

Publication History

Publication Date:
22 June 2010 (online)

Significance

The authors report an unprecedented application of self-activated boronic esters in a base-free cross-coupling reaction with diazonium salts under mild and user-friendly conditions. The protocol tolerates a wide range of functional groups and affords unsymmetrical biaryls in high yields.