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Synfacts 2010(7): 0796-0796
DOI: 10.1055/s-0029-1220028
DOI: 10.1055/s-0029-1220028
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Electronically Tunable Chiral Ligands for Rhodium-Catalyzed Conjugate Addition
Y. Luo, A. J. Carnell*
University of Liverpool, UK
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
The scaleable chemoenzymatic synthesis provides a practical synthetic route to chiral diene ligands. The flexibility of the synthesis allows for electronic tuning of the ligands, which show improved activity and enantioselectivity in conjugate additions.