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Synfacts 2010(7): 0740-0740
DOI: 10.1055/s-0029-1220017
DOI: 10.1055/s-0029-1220017
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of TS-071
et al. H. Kakinuma*
Taisho Pharmaceutial Co., Saitama-shi, Japan
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
TS-071 is a C-thioglycoside that selectively inhibits SGLT2 (sodium-dependent glucose cotransporter 2) and consequently aids normalization of plasma glucose levels in diabetics by preventing renal glucose absorption and promoting glucose excretion in the urine. It is related to dapagliflozin, a selective SGLT2 inhibitor in phase III clinical trials for the treatment of type 2 diabetes.