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Synlett 2010(9): 1418-1420  
DOI: 10.1055/s-0029-1219904
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

A Novel Method for the Synthesis of 2-Trifluoromethylindoles from N-(o-Haloaryl)alkynylimines

Zixian Chena,b, Jiangtao Zhua, Haibo Xiea, Shan Lia, Yongming Wu*a, Yuefa Gong*b
a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. of China
Fax: +86(21)54925192; e-Mail: ymwu@mail.sioc.ac.cn;
b School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P. R. of China
e-Mail: gongyf@mail.hust.edu.cn;
Further Information

Publication History

Received 3 March 2010
Publication Date:
20 April 2010 (online)

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Abstract

Treatment of various types of N-(o-haloaryl)-alkynylimines in the presence of Pd(PPh3)2Cl2 gave 2-trifluoromethylindoles in high yields. This approach provides a novel and facile access to the biologically important fluorine-containing indole derivatives.

Key words

indoles - trifluoromethyl - palladium - alkynylimine - heterocycles

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