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Synfacts 2010(6): 0676-0676  
DOI: 10.1055/s-0029-1219858
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

P-Stereogenic Diphosphine Ligands for Asymmetric Hydrogenation

Contributor(s): Mark Lautens, Stephen G. Newman
B. Zupančič, B. Mohar, M. Stephan*
National Institute of Chemistry, Ljubljana, Slovenia and PhosPhoenix, Paris, France
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Asymmetric alkene hydrogena-tion is perhaps the most important and efficient method for synthesizing chiral molecules, with Knowles’ pioneering RhDiPAMP catalyst being particularly effective. Stephan and co-workers ­recently synthesized analogues of DiPAMP, often observing improved activities and enantioselectivities (Adv. Synth. Catal. 2008, 350, 2024). As a continuation of this work, the authors explore the reactivity of their t-Bu-SMS-Phos ligand in the rhodium-catalyzed reduction of a diverse range of prochiral olefins.