RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
PDF herunterladen
Synfacts 2010(4): 0446-0446
DOI: 10.1055/s-0029-1219475
DOI: 10.1055/s-0029-1219475
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New YorkSynthesis of Chiral Benzoazepines through Allylic Substitution
H. He, W.-B. Liu, L.-X. Dai, S.-L. You*
Shanghai Institute of Organic Chemistry, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. März 2010 (online)
Significance
The authors describe an efficient synthesis of chiral benzoazepines through a double allylic substitution reaction. This work further demonstrates the wide applicability and utility of asymmetric iridium-catalyzed allylic substitutions as pioneered by Helmchen and Hartwig (see Review below). Compounds featuring this structural motif possess diverse biological activity and asymmetric methods towards their synthesis are noteworthy.
Review: For a review on allylic substitutions, see: R. Takeuchi, S. Kezuka Synthesis 2006, 3349-3366.