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Synfacts 2010(4): 0390-0390  
DOI: 10.1055/s-0029-1219449
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Iriomoteolide 3a

Contributor(s): Steven V. Ley, Kimberley A. Roper
R. Cribiú, C. Jäger, C. Nevado*
Universität Zürich, Switzerland
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Publikationsdatum:
22. März 2010 (online)

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Significance

Iriomoteolide 3a was recently isolated from marine algae and shows anticancer properties with potent cytotoxicity in the low nM range. The synthesis of this unusual 15-membered macrocycle was completed using a clever ring-closing metathesis (RCM) strategy utilizing the power of silicon-directed reactivity.