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DOI: 10.1055/s-0029-1219198
Enantioselective α-Chlorination of Aldehydes with Recyclable Fluorous (S)-Pyrrolidine-Thiourea Bifunctional Organocatalyst
Publikationsverlauf
Publikationsdatum:
15. Januar 2010 (online)
Abstract
A novel fluorous (S)-pyrrolidine-thiourea bifunctional organocatalyst is prepared. The catalyst shows good activity and enantioselectivity for direct α-chlorination of aldehydes using N-chlorosuccinimide (NCS) as the chlorine source. It can be recovered from the reaction mixture by fluorous solid-phase extraction with excellent purity for direct reuse.
Key words
bifunctional organocatalyst - α-chlorination - α-chloroaldehyde - N-chlorosuccinimide (NCS) - fluorous catalyst - fluorous solid-phase extraction (F-SPE)
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References and Notes
Fluorous columns and products were purchased from Fluorous Technologies, Inc. D.P.C. owns an equity interest in this company.