Ruthenium Lewis Acid Catalyzed Asymmetric 1,3-Dipolar Cycloadditions between N-Methylnitrones and Enals

Abstract

N-Methylisoxazolidines are formed in good yields and high regio-, diastereo- and enantioselectivity via asymmetric 1,3-dipolar cycloaddition of nitrones with enals catalyzed by a chiral ruthenium Lewis acid. Electronic effects in the dipole are the key to activation of these substrates for efficient catalysis.

asymmetric catalysis - Lewis acid - ruthenium - N-methyl nitrones - 1,3-dipolar cycloaddition

References

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