A Mild and Efficient Catalytic
Mannich-Type Reaction as a Simple Access to N-Benzyloxycarbonyl β-Amino
Ketones

Biswanath Das; Gandolla Chinna Reddy; Penagaluri Balasubramanyam; Boyapati Veeranjaneyulu

doi:10.1055/s-0029-1218728

PAPER

A Mild and Efficient Catalytic Mannich-Type Reaction as a Simple Access to N-Benzyloxycarbonyl β-Amino Ketones [¹]

Biswanath Das*, Gandolla Chinna Reddy, Penagaluri Balasubramanyam, Boyapati Veeranjaneyulu
Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27193198; e-Mail: biswanathdas@yahoo.com;

Abstract

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Abstract

N-Benzyloxycarbonylamino sulfones react with aromatic ketones in the presence of catalytic amount of boron trifluoride-diethyl ether at room temperature to afford the corresponding protected β-amino ketones in high yields (71-87%).

Key words

α-amido sulfones - stable imine precursors - aromatic ketones - BF₃˙OEt₂ - Lewis acids - β-amino ketones

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References

Part 200 in the series ‘Studies on Novel Synthetic Methodologies’.

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