New Tricyclic Ring Systems of Fused 1,4-Diazepines

Barbara Zaleska; Marcin Karelus; Pawe Serda

doi:10.1055/s-0029-1218710

PAPER

New Tricyclic Ring Systems of Fused 1,4-Diazepines

Barbara Zaleska*^a, Marcin Karelus^a, Pawe Serda^b
^a Department of Organic Chemistry, Jagiellonian University, ul. R. Ingardena 3, 30-060 Kraków, Poland
Fax: 48(12)6340515; e-Mail: zaleska@chemia.uj.edu.pl;
^b Regional Laboratory of Physicochemical Analysis and Structural Research, ul. R. Ingardena 3, 30-060 Kraków, Poland

Abstract

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Abstract

New heterocyclic systems of pyrimido[1,2-d][1,4]diazepine, [1,4]diazepino[7,1-b]quinazoline, and [1,4]diazepino[1,7-a][1,3]diazepine were obtained in specific reactions of DMAD with zwitterionic compounds.

Key words

pyrimido[1,2-d][1,4]diazepine - [1,4]diazepino[7,1-b]quinazoline - [1,4]diazepino[1,7-a][1,3]diazepine - triazatricyclo[7.2.1.0^³,8]dodec-7-ene - DMAD

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Referenzen

References

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Compound 11 with formula C₁₈H₁₉N₃O₄S crystallises in the triclinic system, space group P1, with unit cell parameters a = 8.8020 (2), b = 10.1138 (2), c = 11.1187 (2) Å, α = 74.932 (1), β = 75.122 (1), γ = 74.018 (1)˚, V = 900.36 (3) Å^³, Z = 2. A total of 4115 independent reflections [R(int) = 0.0278] were collected on a sample (size 0.3 × 0.2 × 0.15 mm) using KappaCCD diffractometer and MoKα radiation. The structure was solved by direct methods with SHELXS97^¹4 and refined by the full-matrix least-squares method on F ^² using SHELXL97^¹5 program. Final discrepancy indices for I > 2σ(I) were equal R1 = 0.0573, wR2 = 0.1048 and R1 = 0.091, wR2 = 0.1642 for all data. The final difference Fourier map of electron density had the largest peak and hole of 0.61 and -0.305 e˙Å^-³, respectively. All calculations and molecular graphics were done using the WinGX package.^¹6 The structural data were deposited at the Cambridge Crystallographic Data Centre. These data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retrieving.html, or from the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 (1223)336033; e-mail: deposit@ccdc.cam.ac.uk, under reference number CCDC 720638

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